San Diego — Des Moines flights are offered by 4 airline(s) including Delta Air Lines, United Airlines, Spirit Airlines, Southwest Airlines.
The cheapest one-way flights are usually available on a Tuesday. The average price of a one-way flight is currently $ 158.12. The lowest price is $ 129.71 departing on local with Southwest Airlines. San Diego - SAN is the cheapest airport for flights San Diego – Des Moines.