Cheap flights from San Luis Obispo to Des Moines from $341

Travelers frequently search for route combinations, such as San Luis Obispo and Seattle, Puerto Vallarta, Portland, Denver, Spokane, Columbus, Palm Springs, Detroit, Omaha, Sylhet, Tijuana, Cúcuta, Tirana, Honolulu, Saint Thomas, Santa Cruz de la Sierra, Puerto Escondido, Oaxaca, Norfolk, Indianapolis, Madrid.

Travelers frequently search for route combinations, such as Des Moines and Los Angeles, Seattle, Washington, D.C., Las Vegas, Denver, Nashville, New York, Fort Lauderdale, Orlando, Boston, Idaho Falls, Santa Ana, Salt Lake City, Portland, Detroit, Sacramento, Kauai, Phoenix, Charleston, Burbank.

The main airport in San Luis Obispo is San Luis Obispo County Regional. It is also served by Fresno Yosemite International, Hollywood Burbank, Monterey Regional, San Luis Obispo County Regional, Santa Barbara Municipal, Santa Maria Public, Meadows Field.

The main airport in Des Moines is Des Moines International. It is also served by Eppley Airfield, Des Moines International, The Eastern Iowa, Southeast Iowa Regional, Kirksville Regional, Waterloo Regional, Fort Dodge Regional, Mason City Municipal, Sioux Gateway.

Currently, you can fly between San Luis Obispo and Des Moines with American Airlines.

If you don’t have specific dates for your trip between San Luis Obispo and Des Moines, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between San Luis Obispo and Des Moines, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around San Luis Obispo. The main one is San Luis Obispo County Regional and other nearby airports include Fresno Yosemite International, Hollywood Burbank, Monterey Regional, San Luis Obispo County Regional, Santa Barbara Municipal, Santa Maria Public, Meadows Field

There are a number of airports in and around Des Moines. The main one is Des Moines International and other nearby airports include Eppley Airfield, Des Moines International, The Eastern Iowa, Southeast Iowa Regional, Kirksville Regional, Waterloo Regional, Fort Dodge Regional, Mason City Municipal, Sioux Gateway.