Cheap flights from Santa Ana, CA to Mayagüez, United States

Travelers frequently search for route combinations, such as Santa Ana and Denver, Las Vegas, Austin, Atlanta, New York, San Jose, Nashville, Sacramento, Washington, D.C., Oakland, Fort Lauderdale, Detroit, Chicago, San Antonio, Dallas, Minneapolis, Houston, St. Louis, Phoenix, Portland.

Travelers frequently search for route combinations, such as Mayagüez and Philadelphia, New York, Orlando, Atlanta, Tampa, Cleveland, Saint Croix, Santo Domingo, Cincinnati, Phoenix, Boston, Las Vegas, Denver, Chicago, Miami, Los Angeles, Dallas, San Francisco, Houston, San Juan.

The main airport in Santa Ana is John Wayne. It is also served by Tijuana International, San Diego International, Ontario International, John Wayne, Hollywood Burbank, Palm Springs International, Long Beach, Santa Barbara Municipal, Imperial County, Meadows Field.

The main airport in Mayagüez is Eugenio María de Hostos. It is also served by Luis Muñoz Marín International, Aguadilla Rafael Hernandez, José Aponte de la Torre, Fernando Luis Ribas Dominicci, Eugenio María de Hostos, Mercedita.

Yes, it's possible to combine different modes of transport between Santa Ana and Mayagüez thanks to our Virtual Interlining technology. Making use of not only flights but also trains and buses between Santa Ana and Mayagüez can give rise to new adventures. Read more about how Virtual Interlining works on Kiwi.com Stories.

Virtual Interlining provides a revolutionary way of traveling. You can combine different modes of transport like flights, trains, and buses into one itinerary. And this often saves money. Thanks to the world's largest carrier database, the Kiwi.com search function enables anyone to mix and match different modes of transport easily.

Currently, you can fly between Santa Ana and Mayagüez with Cape Air, Frontier Airlines, Spirit Airlines, Alaska Airlines, JetBlue Airways.

If you don’t have specific dates for your trip between Santa Ana and Mayagüez, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Santa Ana and Mayagüez, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What's more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.