Cheap flights from San Francisco, CA to Mytilene, Greece

Travelers frequently search for route combinations, such as San Francisco and Las Vegas, Paris, Barcelona, Denver, Washington, D.C., Mexico City, Chicago, Guadalajara, London, Atlanta, Rome, Austin, Lisbon, Madrid, New York, Dublin, Amsterdam, New Orleans, Berlin, Athens.

Travelers frequently search for route combinations, such as Mytilene and Athens, New York, Tel Aviv, Berlin, Thessaloniki, Boston, London, Chicago, Seattle, Paris, Kyiv, Bucharest, Los Angeles, Washington, D.C., Amsterdam, Oakland, Denver, Salt Lake City, Detroit, Orlando.

The main airport in San Francisco is San Francisco International. It is also served by San Francisco International, Sacramento International, Oakland International, San Jose International, Stockton Metropolitan, Monterey Regional, Charles M. Schulz–Sonoma County, Merced Regional.

The main airport in Mytilene is Mytilene International. It is also served by Mytilene International, Chios Island National, Balıkesir Koca Seyit, Çanakkale.

Yes, it's possible to combine different modes of transport between San Francisco and Mytilene thanks to our Virtual Interlining technology. Making use of not only flights but also trains and buses between San Francisco and Mytilene can give rise to new adventures. Read more about how Virtual Interlining works on Kiwi.com Stories.

Virtual Interlining provides a revolutionary way of traveling. You can combine different modes of transport like flights, trains, and buses into one itinerary. And this often saves money. Thanks to the world's largest carrier database, the Kiwi.com search function enables anyone to mix and match different modes of transport easily.

Currently, you can fly between San Francisco and Mytilene with Aegean, SKY express, Virgin Atlantic Airways, easyJet, British Airways.

If you don’t have specific dates for your trip between San Francisco and Mytilene, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between San Francisco and Mytilene, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What's more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.