Cheap flights from Appleton to Des Moines from $284

Travelers frequently search for route combinations, such as Appleton and Phoenix, Punta Gorda, Tampa, Fort Lauderdale, Nashville, Orlando, Sarasota, Savannah, Puebla, Birmingham, Louisville, Oakland, Bangor, Bratislava, Bismarck, Kabul, Chiang Mai, Riyadh, Kalispell, Montevideo.

Travelers frequently search for route combinations, such as Des Moines and Nashville, Fort Lauderdale, Las Vegas, Phoenix, Austin, Santa Ana, Denver, New York, London, Los Angeles, Portland, Peoria, Orlando, Guadalajara, Mexico City, Mobile, South Bend, Ontario, Seattle, Jackson.

The main airport in Appleton is Appleton International. It is also served by Appleton International, Chicago Rockford International, General Mitchell International, Dane County Regional, La Crosse Regional, Central Wisconsin, Ford, Delta County, Rhinelander–Oneida County, Green Bay–Austin Straubel International.

The main airport in Des Moines is Des Moines International. It is also served by Des Moines International, Eppley Airfield, The Eastern Iowa, Southeast Iowa Regional, Kirksville Regional, Fort Dodge Regional, Mason City Municipal, Waterloo Regional, Sioux Gateway.

Currently, you can fly between Appleton and Des Moines with United Airlines, Allegiant Air, Spirit Airlines, Frontier Airlines, JetBlue Airways.

If you don’t have specific dates for your trip between Appleton and Des Moines, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Appleton and Des Moines, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Appleton. The main one is Appleton International and other nearby airports include Appleton International, Chicago Rockford International, General Mitchell International, Dane County Regional, La Crosse Regional, Central Wisconsin, Ford, Delta County, Rhinelander–Oneida County, Green Bay–Austin Straubel International

There are a number of airports in and around Des Moines. The main one is Des Moines International and other nearby airports include Des Moines International, Eppley Airfield, The Eastern Iowa, Southeast Iowa Regional, Kirksville Regional, Fort Dodge Regional, Mason City Municipal, Waterloo Regional, Sioux Gateway.