Cheap flights from Key West to Mayagüez from $281

Travelers frequently search for route combinations, such as Key West and Orlando, Tampa, Fort Lauderdale, Cancún, Asheville, Cincinnati, Tallahassee, Pittsburgh, Monterrey, Grand Cayman, Atlanta, New York, Kherson, Istanbul, Budapest, McAllen, Santorini, Johannesburg, Tulsa, Venice.

Travelers frequently search for route combinations, such as Mayagüez and San Juan, Orlando, Columbus, Houston, Denver, Boston, Cleveland, Seattle, Santo Domingo.

The main airport in Key West is Key West International. It is also served by Miami International, Key West International.

The main airport in Mayagüez is Eugenio María de Hostos. It is also served by Luis Muñoz Marín International, Aguadilla Rafael Hernandez, Mercedita, Eugenio María de Hostos.

Currently, you can fly between Key West and Mayagüez with Cape Air, JetBlue Airways, Frontier Airlines, BREEZE, Allegiant Air.

If you don’t have specific dates for your trip between Key West and Mayagüez, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Key West and Mayagüez, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Key West. The main one is Key West International and other nearby airports include Miami International, Key West International

There are a number of airports in and around Mayagüez. The main one is Eugenio María de Hostos and other nearby airports include Luis Muñoz Marín International, Aguadilla Rafael Hernandez, Mercedita, Eugenio María de Hostos.