Cheap flights from Santo Domingo to Mayagüez from $221

Travelers frequently search for route combinations, such as Santo Domingo and Miami, San Juan, Philadelphia, New York, Orlando, Fort Lauderdale, Atlanta, Washington, D.C., Houston, Dallas, Tampa, Saint Thomas, Charlotte, Hartford, Sacramento, Saint Croix, Boston, Raleigh, Medellín, Phoenix.

Travelers frequently search for route combinations, such as Mayagüez and San Juan, Orlando, Columbus, Key West, Houston, Denver, Boston, Cleveland, Seattle.

Santo Domingo is mainly served by Las Américas International. But there are other airports nearby, including La Isabela International.

The main airport in Santo Domingo is Las Américas International. It is also served by Punta Cana International, Cibao International, Gregorio Luperón International, La Romana International, Samaná El Catey International.

The main airport in Mayagüez is Eugenio María de Hostos. It is also served by Luis Muñoz Marín International, Aguadilla Rafael Hernandez, Mercedita, Eugenio María de Hostos, Fernando Luis Ribas Dominicci.

Currently, you can fly between Santo Domingo and Mayagüez with Cape Air, JetBlue Airways, Sunrise Airways, Frontier Airlines, interCaribbean Airways.

If you don’t have specific dates for your trip between Santo Domingo and Mayagüez, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Santo Domingo and Mayagüez, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Santo Domingo. The main one is Las Américas International and other nearby airports include Punta Cana International, Cibao International, Gregorio Luperón International, La Romana International, Samaná El Catey International