Cheap flights from Knoxville to Charleston from $242

Travelers frequently search for route combinations, such as Knoxville and Fort Lauderdale, Houston, Orlando, Tampa, Phoenix, Denver, Buenos Aires, Mexico City, Boston, Berlin, Belleville, Toronto, Ahmedabad, Destin, Seoul, Bucharest, Casablanca, Tehran, Reykjavik, Chicago.

Travelers frequently search for route combinations, such as Charleston and Orlando, Boston, New York, Phoenix, Seattle, Honolulu, Cincinnati, Miami, Dallas, Denver, Salt Lake City, Cleveland, San Antonio, Fort Lauderdale, Atlanta, Kansas City, Omaha, Pittsburgh, Sacramento, Nashville.

The main airport in Knoxville is McGhee Tyson. It is also served by Nashville International, McGhee Tyson, Asheville Regional, Greenville–Spartanburg International, Chattanooga Metropolitan, Tri-Cities Regional, Blue Grass.

The main airport in Charleston is Yeager. It is also served by John Glenn Columbus International, Tri-Cities Regional, Rickenbacker International, Yeager, Raleigh County Memorial, Roanoke–Blacksburg Regional, Tri-State, Mid-Ohio Valley Regional, North Central West Virginia, Greenbrier Valley.

Currently, you can fly between Knoxville and Charleston with BREEZE, JetBlue Airways, WestJet, Frontier Airlines.

If you don’t have specific dates for your trip between Knoxville and Charleston, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Knoxville and Charleston, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Knoxville. The main one is McGhee Tyson and other nearby airports include Nashville International, McGhee Tyson, Asheville Regional, Greenville–Spartanburg International, Chattanooga Metropolitan, Tri-Cities Regional, Blue Grass

There are a number of airports in and around Charleston. The main one is Yeager and other nearby airports include John Glenn Columbus International, Tri-Cities Regional, Rickenbacker International, Yeager, Raleigh County Memorial, Roanoke–Blacksburg Regional, Tri-State, Mid-Ohio Valley Regional, North Central West Virginia, Greenbrier Valley.