Cheap flights from Knoxville to Panama City from $437

Travelers frequently search for route combinations, such as Knoxville and Fort Lauderdale, Houston, Orlando, Tampa, Phoenix, Denver, Buenos Aires, Mexico City, Boston, Berlin, Belleville, Toronto, Ahmedabad, Destin, Seoul, Bucharest, Casablanca, Tehran, Reykjavik, Chicago.

Travelers frequently search for route combinations, such as Panama City and Philadelphia, Atlanta, Istanbul, Richmond, Grand Rapids, Omaha, Nashville, Hartford, Guadalajara, Bismarck, Sioux Falls, Fargo, Cincinnati, Phoenix, Tucson, Columbus, Reno, Boston, Albany, Milwaukee.

The main airport in Knoxville is McGhee Tyson. It is also served by Nashville International, Asheville Regional, Greenville–Spartanburg International, McGhee Tyson, Blue Grass, Chattanooga Metropolitan, Tri-Cities Regional.

The main airport in Panama City is Northwest Florida Beaches International. It is also served by Pensacola International, Destin–Fort Walton Beach, Tallahassee International, Montgomery Regional, Southwest Georgia Regional, Valdosta Regional, Dothan Regional.

Currently, you can fly between Knoxville and Panama City with United Airlines, WestJet, Allegiant Air, Porter Airlines, Air Canada.

If you don’t have specific dates for your trip between Knoxville and Panama City, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Knoxville and Panama City, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Knoxville. The main one is McGhee Tyson and other nearby airports include Nashville International, Asheville Regional, Greenville–Spartanburg International, McGhee Tyson, Blue Grass, Chattanooga Metropolitan, Tri-Cities Regional

There are a number of airports in and around Panama City. The main one is Northwest Florida Beaches International and other nearby airports include Pensacola International, Destin–Fort Walton Beach, Tallahassee International, Montgomery Regional, Southwest Georgia Regional, Valdosta Regional, Dothan Regional.