Cheap flights from Knoxville to San Diego from $220

Travelers frequently search for route combinations, such as Knoxville and Fort Lauderdale, Houston, Orlando, Tampa, Phoenix, Denver, Buenos Aires, Mexico City, Boston, Berlin, Belleville, Toronto, Ahmedabad, Destin, Seoul, Bucharest, Casablanca, Tehran, Reykjavik, Chicago.

Travelers frequently search for route combinations, such as San Diego and San Francisco, San Jose, New York, Las Vegas, Sacramento, Calgary, London, Seattle, Phoenix, Dallas, Denver, Houston, Washington, D.C., Tokyo, Oakland, Chicago, Minneapolis, Honolulu, Vancouver, Portland.

The main airport in Knoxville is McGhee Tyson. It is also served by Nashville International, McGhee Tyson, Asheville Regional, Greenville–Spartanburg International, Chattanooga Metropolitan, Blue Grass, Tri-Cities Regional.

The main airport in San Diego is San Diego International. It is also served by Tijuana International, John Wayne, Ontario International, Hollywood Burbank, Palm Springs International, Mexicali International, Long Beach, Imperial County, Yuma International, Hawthorne Municipal.

Currently, you can fly between Knoxville and San Diego with Allegiant Air, Frontier Airlines, United Airlines, JetBlue Airways, Alaska Airlines.

If you don’t have specific dates for your trip between Knoxville and San Diego, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Knoxville and San Diego, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Knoxville. The main one is McGhee Tyson and other nearby airports include Nashville International, McGhee Tyson, Asheville Regional, Greenville–Spartanburg International, Chattanooga Metropolitan, Blue Grass, Tri-Cities Regional

There are a number of airports in and around San Diego. The main one is San Diego International and other nearby airports include Tijuana International, John Wayne, Ontario International, Hollywood Burbank, Palm Springs International, Mexicali International, Long Beach, Imperial County, Yuma International, Hawthorne Municipal.