Cheap flights from Knoxville to Santiago de Chile from $374

Travelers frequently search for route combinations, such as Knoxville and Fort Lauderdale, Houston, Orlando, Tampa, Phoenix, Denver, Buenos Aires, Mexico City, Boston, Berlin, Belleville, Toronto, Ahmedabad, Destin, Seoul, Bucharest, Casablanca, Tehran, Reykjavik, Chicago.

Travelers frequently search for route combinations, such as Santiago de Chile and Los Angeles, San Francisco, Atlanta, Houston, Fort Lauderdale, Denver, New York, Buenos Aires, Washington, D.C., Orlando, Miami, Chicago, Boston, Minneapolis, San Juan, São Paulo, Lima, Mendoza, Portland, Reno.

The main airport in Knoxville is McGhee Tyson. It is also served by Nashville International, McGhee Tyson, Greenville–Spartanburg International, Asheville Regional, Blue Grass, Chattanooga Metropolitan, Tri-Cities Regional.

The main airport in Santiago de Chile is Comodoro Arturo Merino Benítez International. It is also served by Comodoro Arturo Merino Benítez International.

Currently, you can fly between Knoxville and Santiago de Chile with Allegiant Air, LATAM Airlines, Spirit Airlines, Copa Airlines, Avianca.

If you don’t have specific dates for your trip between Knoxville and Santiago de Chile, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Knoxville and Santiago de Chile, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Knoxville. The main one is McGhee Tyson and other nearby airports include Nashville International, McGhee Tyson, Greenville–Spartanburg International, Asheville Regional, Blue Grass, Chattanooga Metropolitan, Tri-Cities Regional

There are a number of airports in and around Santiago de Chile. The main one is Comodoro Arturo Merino Benítez International and other nearby airports include Comodoro Arturo Merino Benítez International.