Cheap flights from Knoxville to Santiago de los Caballeros from $264

Travelers frequently search for route combinations, such as Knoxville and Fort Lauderdale, Houston, Orlando, Tampa, Phoenix, Denver, Buenos Aires, Mexico City, Boston, Berlin, Belleville, Toronto, Ahmedabad, Destin, Seoul, Bucharest, Casablanca, Tehran, Reykjavik, Chicago.

Travelers frequently search for route combinations, such as Santiago de los Caballeros and New York, Fort Lauderdale, San Juan, Atlanta, Houston, Boston, Miami, Dallas, Philadelphia, Detroit, Washington, D.C., New Orleans, San José, Cancún, San Salvador, Panama, Columbus, Toledo, Portland, Sacramento.

The main airport in Knoxville is McGhee Tyson. It is also served by Nashville International, Greenville–Spartanburg International, Asheville Regional, McGhee Tyson, Chattanooga Metropolitan, Blue Grass, Tri-Cities Regional.

The main airport in Santiago de los Caballeros is Cibao International. It is also served by Las Américas International, Cap-Haïtien International, Cibao International, La Isabela International, Gregorio Luperón International, La Romana International, Samaná El Catey International.

Currently, you can fly between Knoxville and Santiago de los Caballeros with JetBlue Airways, Allegiant Air, BREEZE, Frontier Airlines, WestJet.

If you don’t have specific dates for your trip between Knoxville and Santiago de los Caballeros, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Knoxville and Santiago de los Caballeros, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Knoxville. The main one is McGhee Tyson and other nearby airports include Nashville International, Greenville–Spartanburg International, Asheville Regional, McGhee Tyson, Chattanooga Metropolitan, Blue Grass, Tri-Cities Regional

There are a number of airports in and around Santiago de los Caballeros. The main one is Cibao International and other nearby airports include Las Américas International, Cap-Haïtien International, Cibao International, La Isabela International, Gregorio Luperón International, La Romana International, Samaná El Catey International.