Cheap flights from Knoxville to Tupelo from $164

Travelers frequently search for route combinations, such as Knoxville and Fort Lauderdale, Houston, Orlando, Tampa, Phoenix, Denver, Buenos Aires, Mexico City, Boston, Berlin, Belleville, Toronto, Ahmedabad, Destin, Seoul, Bucharest, Casablanca, Tehran, Reykjavik, Chicago.

Travelers frequently search for route combinations, such as Tupelo and Sarasota, Dallas, Raleigh, Pittsburgh, Philadelphia, Washington, D.C., Seattle, Charlotte, Boston, Charleston, Midland, Columbus, Los Angeles, Norfolk, Sioux Falls, Des Moines, Phoenix, Little Rock, Omaha, Reno.

The main airport in Knoxville is McGhee Tyson. It is also served by Nashville International, McGhee Tyson, Asheville Regional, Greenville–Spartanburg International, Chattanooga Metropolitan, Blue Grass, Tri-Cities Regional.

The main airport in Tupelo is Tupelo Regional. It is also served by Memphis International, Huntsville International, Birmingham-Shuttlesworth International, Jonesboro Municipal, Tupelo Regional, Northwest Alabama Regional, McKellar–Sipes Regional, Meridian Regional, Golden Triangle Regional.

Currently, you can fly between Knoxville and Tupelo with Allegiant Air, United Airlines, Spirit Airlines, Frontier Airlines.

If you don’t have specific dates for your trip between Knoxville and Tupelo, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Knoxville and Tupelo, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Knoxville. The main one is McGhee Tyson and other nearby airports include Nashville International, McGhee Tyson, Asheville Regional, Greenville–Spartanburg International, Chattanooga Metropolitan, Blue Grass, Tri-Cities Regional

There are a number of airports in and around Tupelo. The main one is Tupelo Regional and other nearby airports include Memphis International, Huntsville International, Birmingham-Shuttlesworth International, Jonesboro Municipal, Tupelo Regional, Northwest Alabama Regional, McKellar–Sipes Regional, Meridian Regional, Golden Triangle Regional.