Cheap flights from Portland to Des Moines from $138

Travelers frequently search for route combinations, such as Portland and Guadalajara, Mexico City, Los Angeles, Las Vegas, Phoenix, San Francisco, Oaxaca, Denver, Kailua, San Diego, Ontario, Chicago, Puerto Escondido, Oaxaca, New York, Calgary, San José del Cabo, London, Dallas, Puerto Vallarta, Tokyo.

Travelers frequently search for route combinations, such as Des Moines and Nashville, Fort Lauderdale, Las Vegas, Phoenix, Austin, Santa Ana, Denver, New York, London, Los Angeles, Peoria, Orlando, Guadalajara, Mexico City, Mobile, South Bend, Ontario, Seattle, Jackson, Amarillo.

The main airport in Portland is Portland International. It is also served by Seattle–Tacoma International, Portland International, Eugene, Roberts Field, Boeing Field, Kenmore Air Harbor Seaplane Base.

The main airport in Des Moines is Des Moines International. It is also served by Eppley Airfield, Des Moines International, The Eastern Iowa, Mason City Municipal, Southeast Iowa Regional, Fort Dodge Regional, Waterloo Regional, Kirksville Regional, Sioux Gateway.

Currently, you can fly between Portland and Des Moines with United Airlines, Frontier Airlines, Allegiant Air, Alaska Airlines, Sun Country Airlines.

If you don’t have specific dates for your trip between Portland and Des Moines, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Portland and Des Moines, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Portland. The main one is Portland International and other nearby airports include Seattle–Tacoma International, Portland International, Eugene, Roberts Field, Boeing Field, Kenmore Air Harbor Seaplane Base

There are a number of airports in and around Des Moines. The main one is Des Moines International and other nearby airports include Eppley Airfield, Des Moines International, The Eastern Iowa, Mason City Municipal, Southeast Iowa Regional, Fort Dodge Regional, Waterloo Regional, Kirksville Regional, Sioux Gateway.