San Diego, CA to St. Louis, MO flights from $53

Flights starting at $53. Choose between United Airlines, American Airlines, or Delta Air Lines to find the best price.

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One-way trips

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San Diego SANLas Vegas LASSt. Louis STL

Multiple carriers

$67
San Diego SANOrlando MCOSt. Louis STL

Frontier Airlines

$93

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Travelers usually depart from San Diego International, San Diego, CA Bus Station, San Diego, CA - Old Town, McClellan–Palomar, or San Diego, CA - La Jolla when they travel from San Diego to St. Louis. Book your trip to arrive at St. Louis Lambert International, or St. Louis Union Station. The most popular airlines for this route are United Airlines, American Airlines, Delta Air Lines, Frontier Airlines, and Spirit Airlines. San Diego and St. Louis have 395 direct flights per week.

Check-in for a flight from San Diego to St. Louis

NameCarrier codeIATA CodePassport needed during bookingOnline check-in available
United AirlinesUALUAYesNo
American AirlinesAALAAYesNo
Delta Air LinesDALDLYesOpens 24 days before flight
Closes 1 hours before flight
Frontier AirlinesFFTF9NoOpens 24 days before flight
Closes 1 hours before flight
Spirit AirlinesNKSNKNoOpens 24 days before flight
Closes 1 hours before flight

United States COVID-19 travel restrictions

Your trip summary

Most travelers from San Diego, SAN can enter St Louis, STL.

Departure

Additional information
  • Masks are recommended in certain settings

Information is provided as guidance only and accurate at the time of publishing. Always check government websites and airline materials before booking and traveling.

Learn more about COVID-19 restrictions in United States in our dedicated Stories article.

Frequently asked questions

What are the most popular routes to and from San Diego?
Travelers frequently search for route combinations, such as San Diego and Las Vegas, Denver, Austin, Cincinnati, Philadelphia, New York, Atlanta, Washington, D.C., Raleigh, Chicago, Phoenix, Orlando, San Antonio, Charlotte, Minneapolis, Detroit, Cleveland, New Orleans, Dallas, San Francisco.
What are the most popular routes to and from St. Louis?
Travelers frequently search for route combinations, such as St. Louis and Los Angeles, Denver, Las Vegas, Atlanta, San Francisco, Orlando, Minneapolis, Phoenix, Sacramento, Seattle, Houston, New York, Fort Lauderdale, Washington, D.C., Salt Lake City, San Jose, Oakland, Portland, Fresno, London.
Which airports are there in San Diego?
San Diego is mainly served by San Diego International. But there are other airports nearby, including Marine Corps Air Station Miramar, McClellan–Palomar.
What airports are near San Diego?
The main airport in San Diego is San Diego International. It is also served by Los Angeles International, Tijuana International, John Wayne, Ontario International, Hollywood Burbank, Mexicali International, Palm Springs International, Long Beach, Imperial County, Yuma International.
What airports are near St. Louis?
The main airport in St. Louis is St. Louis Lambert International. It is also served by St. Louis Lambert International, General Wayne A. Downing Peoria International, Central Illinois Regional, Cape Girardeau Regional, Waynesville-St. Robert Regional, MidAmerica St. Louis, Barkley Regional, Evansville Regional, Williamson County Regional, Quincy Regional.
Is it possible to combine flights, buses, and trains in one itinerary when traveling between San Diego and St. Louis?
Yes, it's possible to combine different modes of transport between San Diego and St. Louis thanks to our Virtual Interlining technology. Making use of not only flights but also trains and buses between San Diego and St. Louis can give rise to new adventures. Read more about how Virtual Interlining works on Kiwi.com Stories.
What is Virtual Interlining and how do I use it?
Virtual Interlining provides a revolutionary way of traveling. You can combine different modes of transport like flights, trains, and buses into one itinerary. And this often saves money. Thanks to the world's largest carrier database, the Kiwi.com search function enables anyone to mix and match different modes of transport easily.
Which airlines fly between San Diego and St. Louis?
Currently, you can fly between San Diego and St. Louis with United Airlines, American Airlines, Delta Air Lines, Frontier Airlines, Spirit Airlines.
When's the best time to travel between San Diego and St. Louis?
If you don’t have specific dates for your trip between San Diego and St. Louis, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.
What flights operate between San Diego and St. Louis?
How many airports are there near San Diego?
How many airports are there near St. Louis?
What time do nonstop (direct) flights between San Diego and St. Louis depart?
What time do nonstop (direct) flights between San Diego and St. Louis arrive?
What time do flights between San Diego and St. Louis depart?
What time do flights between San Diego and St. Louis arrive?

Planning a trip? Thanks to our Virtual Interlining algorithm, we offer billions of route combinations between any A and any B in the world by plane, train, and bus. Find the cheapest routes and best deals for you, as well as the best dates on which to travel.

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Flights to St. Louis

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