San Diego, CA to St. Louis, MO flights from $53

Travelers frequently search for route combinations, such as San Diego and Las Vegas, Denver, Austin, Cincinnati, Philadelphia, New York, Atlanta, Washington, D.C., Raleigh, Chicago, Phoenix, Orlando, San Antonio, Charlotte, Minneapolis, Detroit, Cleveland, New Orleans, Dallas, San Francisco.

Travelers frequently search for route combinations, such as St. Louis and Los Angeles, Denver, Las Vegas, Atlanta, San Francisco, Orlando, Minneapolis, Phoenix, Sacramento, Seattle, Houston, New York, Fort Lauderdale, Washington, D.C., Salt Lake City, San Jose, Oakland, Portland, Fresno, London.

San Diego is mainly served by San Diego International. But there are other airports nearby, including Marine Corps Air Station Miramar, McClellan–Palomar.

The main airport in San Diego is San Diego International. It is also served by Los Angeles International, Tijuana International, John Wayne, Ontario International, Hollywood Burbank, Mexicali International, Palm Springs International, Long Beach, Imperial County, Yuma International.

The main airport in St. Louis is St. Louis Lambert International. It is also served by St. Louis Lambert International, General Wayne A. Downing Peoria International, Central Illinois Regional, Cape Girardeau Regional, Waynesville-St. Robert Regional, MidAmerica St. Louis, Barkley Regional, Evansville Regional, Williamson County Regional, Quincy Regional.

Yes, it's possible to combine different modes of transport between San Diego and St. Louis thanks to our Virtual Interlining technology. Making use of not only flights but also trains and buses between San Diego and St. Louis can give rise to new adventures. Read more about how Virtual Interlining works on Kiwi.com Stories.

Virtual Interlining provides a revolutionary way of traveling. You can combine different modes of transport like flights, trains, and buses into one itinerary. And this often saves money. Thanks to the world's largest carrier database, the Kiwi.com search function enables anyone to mix and match different modes of transport easily.

Currently, you can fly between San Diego and St. Louis with United Airlines, American Airlines, Delta Air Lines, Frontier Airlines, Spirit Airlines.

If you don’t have specific dates for your trip between San Diego and St. Louis, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.