Cheap flights from San Francisco to Des Moines from $225

Travelers frequently search for route combinations, such as San Francisco and Calgary, New York, Las Vegas, Los Angeles, Phoenix, Dallas, Toronto, Barcelona, Chicago, Mexico City, San Diego, Vancouver, Denver, Seoul, Ontario, Tokyo, Minneapolis, Paris, Salt Lake City, Atlanta.

Travelers frequently search for route combinations, such as Des Moines and Los Angeles, Seattle, Washington, D.C., Las Vegas, Denver, Nashville, New York, Fort Lauderdale, Orlando, Boston, Idaho Falls, Santa Ana, Salt Lake City, Portland, Detroit, Sacramento, Kauai, Phoenix, Charleston, Burbank.

The main airport in San Francisco is San Francisco International. It is also served by San Francisco International, Oakland International, Sacramento International, San Jose International, Stockton Metropolitan, Charles M. Schulz–Sonoma County, Monterey Regional, Merced Regional.

The main airport in Des Moines is Des Moines International. It is also served by Eppley Airfield, Des Moines International, The Eastern Iowa, Kirksville Regional, Southeast Iowa Regional, Fort Dodge Regional, Mason City Municipal, Waterloo Regional, Sioux Gateway.

Currently, you can fly between San Francisco and Des Moines with United Airlines.

If you don’t have specific dates for your trip between San Francisco and Des Moines, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between San Francisco and Des Moines, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around San Francisco. The main one is San Francisco International and other nearby airports include San Francisco International, Oakland International, Sacramento International, San Jose International, Stockton Metropolitan, Charles M. Schulz–Sonoma County, Monterey Regional, Merced Regional

There are a number of airports in and around Des Moines. The main one is Des Moines International and other nearby airports include Eppley Airfield, Des Moines International, The Eastern Iowa, Kirksville Regional, Southeast Iowa Regional, Fort Dodge Regional, Mason City Municipal, Waterloo Regional, Sioux Gateway.