Cheap flights from San Francisco to Sioux Falls from $351

Travelers frequently search for route combinations, such as San Francisco and Calgary, New York, Las Vegas, Los Angeles, Phoenix, Dallas, Toronto, Barcelona, Chicago, Mexico City, San Diego, Vancouver, Denver, Seoul, Ontario, Tokyo, Minneapolis, Paris, Salt Lake City, Atlanta.

Travelers frequently search for route combinations, such as Sioux Falls and Denver, Los Angeles, Phoenix, Portland, Philadelphia, Nashville, Guatemala City, Tampa, Chicago, Santa Ana, Fort Lauderdale, San Diego, Guadalajara, Jackson, Huntsville, San Antonio, Bozeman, Hartford, Vientiane, Eugene.

The main airport in San Francisco is San Francisco International. It is also served by San Francisco International, Sacramento International, Oakland International, San Jose International, Stockton Metropolitan, Charles M. Schulz–Sonoma County, Monterey Regional, Merced Regional.

The main airport in Sioux Falls is Sioux Falls Regional. It is also served by Sioux Falls Regional, Watertown Regional, Sioux Gateway.

Currently, you can fly between San Francisco and Sioux Falls with United Airlines, Alaska Airlines.

If you don’t have specific dates for your trip between San Francisco and Sioux Falls, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between San Francisco and Sioux Falls, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around San Francisco. The main one is San Francisco International and other nearby airports include San Francisco International, Sacramento International, Oakland International, San Jose International, Stockton Metropolitan, Charles M. Schulz–Sonoma County, Monterey Regional, Merced Regional

There are a number of airports in and around Sioux Falls. The main one is Sioux Falls Regional and other nearby airports include Sioux Falls Regional, Watertown Regional, Sioux Gateway.