Cheap flights from Santiago de Chile to San Francisco from $355

Travelers frequently search for route combinations, such as Santiago de Chile and Miami, New York, Los Angeles, Easter Island, Seattle, Portland, Boston, Calama, Buenos Aires, Puerto Natales, Punta Arenas, Atlanta, Washington, D.C., Austin, Orlando, San Juan, Detroit, San Antonio, Minneapolis, Houston.

Travelers frequently search for route combinations, such as San Francisco and New York, Los Angeles, Mexico City, London, San Diego, Calgary, Las Vegas, Chicago, Tokyo, Burbank, Seoul, Barcelona, Phoenix, Seattle, New Delhi, Portland, Boston, Vancouver, Denver, Paris.

The main airport in Santiago de Chile is Comodoro Arturo Merino Benítez International. It is also served by Comodoro Arturo Merino Benítez International.

The main airport in San Francisco is San Francisco International. It is also served by San Francisco International, Oakland International, Sacramento International, San Jose International, Stockton Metropolitan, Monterey Regional, Charles M. Schulz–Sonoma County, Merced Regional.

Currently, you can fly between Santiago de Chile and San Francisco with Copa Airlines, LATAM Airlines, AeroMéxico, Avianca, Alaska Airlines.

If you don’t have specific dates for your trip between Santiago de Chile and San Francisco, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Santiago de Chile and San Francisco, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Santiago de Chile. The main one is Comodoro Arturo Merino Benítez International and other nearby airports include Comodoro Arturo Merino Benítez International

There are a number of airports in and around San Francisco. The main one is San Francisco International and other nearby airports include San Francisco International, Oakland International, Sacramento International, San Jose International, Stockton Metropolitan, Monterey Regional, Charles M. Schulz–Sonoma County, Merced Regional.