Cheap flights from Des Moines to Pittsburgh from $243

Travelers frequently search for route combinations, such as Des Moines and Las Vegas, Nashville, Phoenix, Austin, Santa Ana, Orlando, Mexico City, Tampa, Boston, Malé, Montreal, Sacramento, Guadalajara, New York, Shanghai, Winnipeg, Houston, San Pedro Sula, Vancouver, Kathmandu.

Travelers frequently search for route combinations, such as Pittsburgh and New York, Orlando, Tampa, Los Angeles, Houston, Phoenix, Raleigh, Atlanta, Fort Lauderdale, New Orleans, Fort Myers, Hartford, Boston, Providence, Charleston, Dallas, Nashville, Destin, Austin, Mexico City.

The main airport in Des Moines is Des Moines International. It is also served by Des Moines International, Eppley Airfield, The Eastern Iowa, Southeast Iowa Regional, Kirksville Regional, Sioux Gateway, Fort Dodge Regional, Mason City Municipal, Waterloo Regional.

The main airport in Pittsburgh is Pittsburgh International. It is also served by Cleveland Hopkins International, Akron–Canton, Erie International, Arnold Palmer Regional, Hagerstown Regional, North Central West Virginia, Mid-Ohio Valley Regional, University Park, Altoona–Blair County, Bradford Regional.

Currently, you can fly between Des Moines and Pittsburgh with United Airlines, Allegiant Air, Spirit Airlines, JetBlue Airways, Frontier Airlines.

If you don’t have specific dates for your trip between Des Moines and Pittsburgh, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Des Moines and Pittsburgh, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Des Moines. The main one is Des Moines International and other nearby airports include Des Moines International, Eppley Airfield, The Eastern Iowa, Southeast Iowa Regional, Kirksville Regional, Sioux Gateway, Fort Dodge Regional, Mason City Municipal, Waterloo Regional

There are a number of airports in and around Pittsburgh. The main one is Pittsburgh International and other nearby airports include Cleveland Hopkins International, Akron–Canton, Erie International, Arnold Palmer Regional, Hagerstown Regional, North Central West Virginia, Mid-Ohio Valley Regional, University Park, Altoona–Blair County, Bradford Regional.