Cheap flights from Des Moines to Santa Ana from $148

A one-way nonstop (direct) flight between Des Moines and Santa Ana takes around 3.6 hours.

The flight distance between Des Moines and Santa Ana is 2297 km.

Travelers frequently search for route combinations, such as Des Moines and Las Vegas, Nashville, Phoenix, Austin, Orlando, Mexico City, Tampa, Boston, Malé, Montreal, Sacramento, Guadalajara, New York, Shanghai, Winnipeg, Houston, San Pedro Sula, Vancouver, Kathmandu, Punta Gorda.

Travelers frequently search for route combinations, such as Santa Ana and Provo, San Francisco, Las Vegas, Seattle, Phoenix, Oakland, Vancouver, Denver, Eugene, Boise, New York, Idaho Falls, Medford, Dallas, Colorado Springs, Washington, D.C., Portland, London, New Orleans, Grand Junction.

The main airport in Des Moines is Des Moines International. It is also served by Des Moines International, Eppley Airfield, The Eastern Iowa, Southeast Iowa Regional, Sioux Gateway, Waterloo Regional, Fort Dodge Regional, Mason City Municipal.

The main airport in Santa Ana is John Wayne. It is also served by Tijuana International, San Diego International, Ontario International, John Wayne, Hollywood Burbank, Palm Springs International, Santa Barbara Municipal, Long Beach, McClellan–Palomar, Imperial County.

Currently, you can fly between Des Moines and Santa Ana with United Airlines, BREEZE, Frontier Airlines, Alaska Airlines.

If you don’t have specific dates for your trip between Des Moines and Santa Ana, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Des Moines and Santa Ana, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.