Cheap flights from Des Moines to Santa Ana from $106

A one-way nonstop (direct) flight between Des Moines and Santa Ana takes around 3.8 hours.

The flight distance between Des Moines and Santa Ana is 2297 km.

Several carriers operate flights between Des Moines and Santa Ana. Airlines offering nonstop (direct) flights include Allegiant Air.

Travelers frequently search for route combinations, such as Des Moines and Las Vegas, Nashville, Phoenix, Austin, Orlando, Mexico City, Tampa, Boston, Malé, Montreal, Sacramento, Guadalajara, New York, Shanghai, Winnipeg, Houston, San Pedro Sula, Vancouver, Kathmandu, Punta Gorda.

Travelers frequently search for route combinations, such as Santa Ana and Provo, San Francisco, Las Vegas, Seattle, Phoenix, Oakland, Vancouver, Denver, Eugene, Boise, New York, Idaho Falls, Medford, Dallas, Colorado Springs, Washington, D.C., Portland, London, New Orleans, Grand Junction.

The main airport in Des Moines is Des Moines International. It is also served by Eppley Airfield, Des Moines International, The Eastern Iowa, Mason City Municipal, Southeast Iowa Regional, Fort Dodge Regional, Waterloo Regional, Kirksville Regional, Sioux Gateway.

The main airport in Santa Ana is John Wayne. It is also served by Tijuana International, San Diego International, Ontario International, John Wayne, Palm Springs International, Hollywood Burbank, Santa Barbara Municipal, Imperial County, Hawthorne Municipal, Long Beach.

Currently, you can fly between Des Moines and Santa Ana with United Airlines, Allegiant Air, Frontier Airlines, Spirit Airlines, JetBlue Airways.

If you don’t have specific dates for your trip between Des Moines and Santa Ana, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.