Cheap flights from Des Moines to San Diego

Flights starting at $113. Choose between United Airlines, Frontier Airlines, or American Airlines to find the best price.

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Travelers usually depart from Des Moines International, or Des Moines when they travel from Des Moines to San Diego. Book your trip to arrive at San Diego International, San Diego, CA - Old Town, San Diego, CA Bus Station, San Diego, CA - La Jolla, or San Diego, CA - Santa Fe. The distance between Des Moines and San Diego is 2296 km. The most popular airlines for this route are United Airlines, Frontier Airlines, American Airlines, Allegiant Air, and Spirit Airlines. Des Moines and San Diego have 187 direct flights per week.

Weekly direct flights

MondaysTuesdaysWednesdaysThursdaysFridaysSaturdaysSundays
Direct flights---1--1
Fly direct with

Allegiant Air on Thursdays, and Sundays.

Check-in for a flight from Des Moines to San Diego

NameCarrier codeIATA CodePassport needed during bookingOnline check-in available
United AirlinesUALUAYesNo
Frontier AirlinesFFTF9NoOpens 24 days before flight
Closes 1 hours before flight
American AirlinesAALAAYesNo
Allegiant AirAAYG4NoOpens 24 days before flight
Closes 1 hours before flight
Spirit AirlinesNKSNKNoOpens 24 days before flight
Closes 1 hours before flight
Learn more about COVID-19 restrictions in United States in our dedicated Stories article.

Frequently asked questions

How long does it take to travel from Des Moines to San Diego?
A one-way nonstop (direct) flight between Des Moines and San Diego takes around 3.3 hours.
What is the flight distance between Des Moines and San Diego?
The flight distance between Des Moines and San Diego is 2296 km.
What airlines offer nonstop (direct) flights between Des Moines and San Diego?
Several carriers operate flights between Des Moines and San Diego. Airlines offering nonstop (direct) flights include Allegiant Air.
What are the most popular routes to and from Des Moines?
Travelers frequently search for route combinations, such as Des Moines and Los Angeles, Phoenix, Las Vegas, Orlando, Denver, San Francisco, Nashville, Salt Lake City, Sacramento, Sarasota, Seattle, Oakland, Washington, D.C., Dallas, Portland, Tampa, Houston, New Orleans, Philadelphia, Chicago.
What are the most popular routes to and from San Diego?
Travelers frequently search for route combinations, such as San Diego and Denver, Las Vegas, Austin, Cincinnati, Philadelphia, New York, Phoenix, Charlotte, Washington, D.C., Atlanta, Raleigh, Chicago, Orlando, San Antonio, Detroit, Dallas, St. Louis, Cleveland, Salt Lake City, Minneapolis.
What airports are near Des Moines?
The main airport in Des Moines is Des Moines International. It is also served by Des Moines International, Eppley Airfield, The Eastern Iowa, Kirksville Regional, Mason City Municipal, Sioux Gateway, Southeast Iowa Regional, Fort Dodge Regional, Waterloo Regional.
What airports are near San Diego?
The main airport in San Diego is San Diego International. It is also served by Ontario International, John Wayne, Tijuana International, Hollywood Burbank, Mexicali International, Palm Springs International, Imperial County, Yuma International, Long Beach, Hawthorne Municipal.
What buses and trains depart from Des Moines?
A number of bus and train companies depart from Des Moines, including Jefferson Lines.
Is it possible to combine flights, buses, and trains in one itinerary when traveling between Des Moines and San Diego?
Yes, it's possible to combine different modes of transport between Des Moines and San Diego thanks to our Virtual Interlining technology. Making use of not only flights but also trains and buses between Des Moines and San Diego can give rise to new adventures. Read more about how Virtual Interlining works on Kiwi.com Stories.
What is Virtual Interlining and how do I use it?
Which airlines fly between Des Moines and San Diego?
When's the best time to travel between Des Moines and San Diego?
What flights operate between Des Moines and San Diego?
How many airports are there near Des Moines?
How many airports are there near San Diego?
Is it possible to reach Des Moines by bus or train?
What time do nonstop (direct) flights between Des Moines and San Diego depart?
What time do nonstop (direct) flights between Des Moines and San Diego arrive?
What time do flights between Des Moines and San Diego depart?
What time do flights between Des Moines and San Diego arrive?

Planning a trip? Thanks to our Virtual Interlining algorithm, we offer billions of route combinations between any A and any B in the world by plane, train, and bus. Find the cheapest routes and best deals for you, as well as the best dates on which to travel.

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