Cheap flights from Des Moines to San Diego from $191

Travelers frequently search for route combinations, such as Des Moines and Phoenix, Fort Lauderdale, Orlando, New York, Salt Lake City, Miami, Mexico City, Los Angeles, Las Vegas, San Francisco, Milan, Santa Ana, Washington, D.C., Boston, Punta Gorda, London, León, Toronto, Paris, Tampa.

Travelers frequently search for route combinations, such as San Diego and Las Vegas, Portland, Dallas, Denver, San Francisco, Salt Lake City, Atlanta, Seattle, New York, Phoenix, Minneapolis, Houston, Reno, Oakland, San Jose, Calgary, Chicago, Sacramento, Detroit, Orlando.

The main airport in Des Moines is Des Moines International. It is also served by Des Moines International, Eppley Airfield, The Eastern Iowa, Sioux Gateway, Kirksville Regional, Mason City Municipal, Fort Dodge Regional, Waterloo Regional, Southeast Iowa Regional.

The main airport in San Diego is San Diego International. It is also served by Tijuana International, John Wayne, Ontario International, Palm Springs International, Mexicali International, Hollywood Burbank, Long Beach, Imperial County, Yuma International, Hawthorne Municipal.

Currently, you can fly between Des Moines and San Diego with United Airlines, American Airlines, Alaska Airlines.

If you don’t have specific dates for your trip between Des Moines and San Diego, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Des Moines and San Diego, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Des Moines. The main one is Des Moines International and other nearby airports include Des Moines International, Eppley Airfield, The Eastern Iowa, Sioux Gateway, Kirksville Regional, Mason City Municipal, Fort Dodge Regional, Waterloo Regional, Southeast Iowa Regional

There are a number of airports in and around San Diego. The main one is San Diego International and other nearby airports include Tijuana International, John Wayne, Ontario International, Palm Springs International, Mexicali International, Hollywood Burbank, Long Beach, Imperial County, Yuma International, Hawthorne Municipal.