Cheap flights from Des Moines to St. Louis

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Travelers usually depart from Des Moines International, or Des Moines when they travel from Des Moines to St. Louis. Book your trip to arrive at St. Louis Lambert International, or St. Louis Union Station. The distance between Des Moines and St. Louis is 417 km. The most popular airlines for this route are United Airlines, American Airlines, Allegiant Air, WN, and Delta Air Lines. Des Moines and St. Louis have 161 direct flights per week.

Weekly flights

MondaysTuesdaysWednesdaysThursdaysFridaysSaturdaysSundays
Number of flights75191623-1414

Fly direct with

WN on Mondays, Tuesdays, Wednesdays, Thursdays, Fridays, Saturdays, and Sundays.

Check-in for a flight from Des Moines to St. Louis

NameCarrier codeIATA CodePassport needed during bookingAirport check-in closesOnline check-in available
United AirlinesUALUAYesUnknownNo
American AirlinesAALAAYesUnknownNo
Allegiant AirAAYG4No4 min before flightNo
WNSWAWNNoUnknownNo
Delta Air LinesDALDLYesUnknownNo

Frequently asked questions

How long does it take to travel from Des Moines to St. Louis?

A one-way nonstop (direct) flight between Des Moines and St. Louis takes around 1.2 hours.

What is the flight distance between Des Moines and St. Louis?

The flight distance between Des Moines and St. Louis is 417 km.

What airlines offer nonstop (direct) flights between Des Moines and St. Louis?

Several carriers operate flights between Des Moines and St. Louis. Airlines offering nonstop (direct) flights include WN.

What are the most popular routes to and from Des Moines?

Travelers frequently search for route combinations, such as Des Moines and Orlando Sanford International, Miami International, Phoenix–Mesa Gateway, Denver International, San Francisco International, Salt Lake City International, Southwest Florida International, Nashville International, Raleigh–Durham International, Ontario International, Hector International.

What are the most popular routes to and from St. Louis?

Travelers frequently search for route combinations, such as St. Louis and Denver International, Charlotte Douglas International, Sacramento International, Indianapolis International, Clinton National, Wichita Dwight D. Eisenhower National, Owensboro–Daviess County Regional, Jonesboro Municipal, Williamson County Regional, Quincy Regional, Waynesville-St. Robert Regional.

What buses and trains depart from Des Moines?

A number of bus and train companies depart from Des Moines, including Jefferson Lines.

Is it possible to combine flights, buses, and trains in one itinerary when traveling between Des Moines and St. Louis?

What is Virtual Interlining and how do I use it?

Which airlines fly between Des Moines and St. Louis?

When's the best time to travel between Des Moines and St. Louis?

What flights operate between Des Moines and St. Louis?

Is it possible to reach Des Moines by bus or train?

What time do nonstop (direct) flights between Des Moines and St. Louis depart?

What time do nonstop (direct) flights between Des Moines and St. Louis arrive?

What time do flights between Des Moines and St. Louis depart?

What time do flights between Des Moines and St. Louis arrive?

Planning a trip? Thanks to our Virtual Interlining algorithm, we offer billions of route combinations between any A and any B in the world by plane, train, and bus. Find the cheapest routes and best deals for you, as well as the best dates on which to travel.

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