Cheap flights from Prague to Chicago from $646

Travelers frequently search for route combinations, such as Prague and New York, Los Angeles, San Francisco, Boston, London, Raleigh, Orlando, Miami, Tel Aviv, Barcelona, Rome, Bucharest, Paris, Atlanta, Seattle, Tampa, Columbus, Washington, D.C., San Juan, Denver.

Travelers frequently search for route combinations, such as Chicago and Mexico City, New York, Guadalajara, Dallas, Houston, Atlanta, Los Angeles, Morelia, Orlando, Philadelphia, León, Tampa, San Francisco, Miami, Denver, Phoenix, Seattle, Monterrey, Las Vegas, Washington, D.C..

The main airport in Prague is Václav Havel Airport Prague. It is also served by Václav Havel Airport Prague, Copernicus Airport Wrocław, Leipzig/Halle Airport, Dresden, Brno–Tuřany, Linz, Pardubice Airport.

The main airport in Chicago is O Hare International. It is also served by Gerald R. Ford International, Dane County Regional, South Bend International, General Mitchell International, Fort Wayne International, General Wayne A. Downing Peoria International, Central Illinois Regional, Quad City International, Muskegon County, Kalamazoo/Battle Creek International.

Currently, you can fly between Prague and Chicago with Ryanair, TAP Portugal, Icelandair, Air Canada, Air Transat.

If you don’t have specific dates for your trip between Prague and Chicago, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Prague and Chicago, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Prague. The main one is Václav Havel Airport Prague and other nearby airports include Václav Havel Airport Prague, Copernicus Airport Wrocław, Leipzig/Halle Airport, Dresden, Brno–Tuřany, Linz, Pardubice Airport

There are a number of airports in and around Chicago. The main one is O Hare International and other nearby airports include Gerald R. Ford International, Dane County Regional, South Bend International, General Mitchell International, Fort Wayne International, General Wayne A. Downing Peoria International, Central Illinois Regional, Quad City International, Muskegon County, Kalamazoo/Battle Creek International.