Cheap flights from San Francisco to Panama City from $424

Traveling between San Francisco and Panama, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around San Francisco. The main one is San Francisco International and other nearby airports include San Francisco International, Sacramento International, Oakland International, San Jose International, Stockton Metropolitan, Monterey Regional, Charles M. Schulz–Sonoma County, Merced Regional

There are a number of airports in and around Panama. The main one is Tocumen International and other nearby airports include Chitre Alonso Valderrama.

This depends on the airline’s flight schedule. You can easily select your preferred departure time when you search on our website or mobile app. Choose the time of day you wish to depart from San Francisco, such as morning, afternoon, evening, or night, or select the exact hours for departure.

This depends on the airline’s flight schedule. You can easily select your preferred arrival time when you search on our website or mobile app. Choose the time of day you wish to arrive at Panama, such as morning, afternoon, evening, or night, or select the exact hours for arrival.

This depends on the airline’s flight schedule. You can easily select your preferred departure time when you search on our website or mobile app. Choose the time of day you wish to depart from San Francisco, such as morning, afternoon, evening, or night, or select the exact hours for departure.

This depends on the airline’s flight schedule. You can easily select your preferred arrival time when you search on our website or mobile app. Choose the time of day you wish to arrive at Panama, such as morning, afternoon, evening, or night, or select the exact hours for arrival.