Cheap flights from St. Louis, MO to San Diego, CA

Flights starting at $74. Choose between United Airlines, Frontier Airlines, or American Airlines to find the best price.

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St. Louis STLLas Vegas LASSan Diego SAN

Multiple carriers

$86
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St. Louis STLDenver DENSan Diego SAN

Multiple carriers

$132

Updated:

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Travelers usually depart from St. Louis Lambert International, or St. Louis Union Station when they travel from St. Louis to San Diego. Book your trip to arrive at San Diego International, San Diego, CA Bus Station, San Diego, CA - Old Town, McClellan–Palomar, or San Diego, CA - La Jolla. The most popular airlines for this route are United Airlines, Frontier Airlines, American Airlines, Delta Air Lines, and Spirit Airlines. St. Louis and San Diego have 401 direct flights per week.

Check-in for a flight from St. Louis to San Diego

NameCarrier codeIATA CodePassport needed during bookingOnline check-in available
United AirlinesUALUAYesNo
Frontier AirlinesFFTF9NoOpens 24 days before flight
Closes 1 hours before flight
American AirlinesAALAAYesNo
Delta Air LinesDALDLYesOpens 24 days before flight
Closes 1 hours before flight
Spirit AirlinesNKSNKNoOpens 24 days before flight
Closes 1 hours before flight

United States COVID-19 travel restrictions

Your trip summary

Most travelers from St Louis, STL can enter San Diego, SAN.

Departure

Additional information
  • Masks are recommended in certain settings

Information is provided as guidance only and accurate at the time of publishing. Always check government websites and airline materials before booking and traveling.

Learn more about COVID-19 restrictions in United States in our dedicated Stories article.

Frequently asked questions

What are the most popular routes to and from St. Louis?
Travelers frequently search for route combinations, such as St. Louis and Las Vegas, Los Angeles, Denver, Orlando, Atlanta, Minneapolis, San Francisco, London, Phoenix, Seattle, Houston, Sacramento, New York, Cancún, Washington, D.C., Fort Lauderdale, Oakland, Tampa, Paris, Dallas.
What are the most popular routes to and from San Diego?
Travelers frequently search for route combinations, such as San Diego and Denver, Las Vegas, Austin, Cincinnati, Philadelphia, New York, Phoenix, Charlotte, Washington, D.C., Atlanta, Raleigh, Chicago, Orlando, San Antonio, Detroit, Dallas, Cleveland, Salt Lake City, Minneapolis, London.
What airports are near St. Louis?
The main airport in St. Louis is St. Louis Lambert International. It is also served by St. Louis Lambert International, General Wayne A. Downing Peoria International, Central Illinois Regional, Cape Girardeau Regional, MidAmerica St. Louis, Waynesville-St. Robert Regional, Barkley Regional, Evansville Regional, Williamson County Regional, Abraham Lincoln Capital.
What airports are near San Diego?
The main airport in San Diego is San Diego International. It is also served by Los Angeles International, John Wayne, Tijuana International, Ontario International, Hollywood Burbank, Mexicali International, Palm Springs International, Imperial County, Long Beach, Yuma International.
Is it possible to combine flights, buses, and trains in one itinerary when traveling between St. Louis and San Diego?
Yes, it's possible to combine different modes of transport between St. Louis and San Diego thanks to our Virtual Interlining technology. Making use of not only flights but also trains and buses between St. Louis and San Diego can give rise to new adventures. Read more about how Virtual Interlining works on Kiwi.com Stories.
What is Virtual Interlining and how do I use it?
Virtual Interlining provides a revolutionary way of traveling. You can combine different modes of transport like flights, trains, and buses into one itinerary. And this often saves money. Thanks to the world's largest carrier database, the Kiwi.com search function enables anyone to mix and match different modes of transport easily.
Which airlines fly between St. Louis and San Diego?
Currently, you can fly between St. Louis and San Diego with United Airlines, Frontier Airlines, American Airlines, Delta Air Lines, Spirit Airlines.
When's the best time to travel between St. Louis and San Diego?
If you don’t have specific dates for your trip between St. Louis and San Diego, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.
What flights operate between St. Louis and San Diego?
Traveling between St. Louis and San Diego, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What's more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.
How many airports are there near St. Louis?
How many airports are there near San Diego?
What time do nonstop (direct) flights between St. Louis and San Diego depart?
What time do nonstop (direct) flights between St. Louis and San Diego arrive?
What time do flights between St. Louis and San Diego depart?
What time do flights between St. Louis and San Diego arrive?

Planning a trip? Thanks to our Virtual Interlining algorithm, we offer billions of route combinations between any A and any B in the world by plane, train, and bus. Find the cheapest routes and best deals for you, as well as the best dates on which to travel.

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