Cheap flights from Knoxville to San Luis Obispo from £253

Travelers frequently search for route combinations, such as Knoxville and London, Glasgow, Las Vegas, Boston, New York, Seattle, Denver, Salt Lake City, Minneapolis, Santo Domingo, San Juan, Dallas, Guatemala City, Los Angeles, Fresno, Fort Lauderdale, Houston, Phnom Penh, Orlando, San Francisco.

Travelers frequently search for route combinations, such as San Luis Obispo and Portland, Reno, San Francisco, Chicago, Cúcuta, Istanbul, Vienna, San Juan, Kahului, Muscat, Munich, Washington, D.C., Tokyo, Frankfurt, Stockholm, Goa, Los Angeles, Punta Cana, Fort Myers, Jeddah.

The main airport in Knoxville is McGhee Tyson. It is also served by Nashville International, McGhee Tyson, Greenville–Spartanburg International, Asheville Regional, Blue Grass, Chattanooga Metropolitan, Tri-Cities Regional.

The main airport in San Luis Obispo is San Luis Obispo County Regional. It is also served by Fresno Yosemite International, Hollywood Burbank, Monterey Regional, Santa Barbara Municipal, San Luis Obispo County Regional, Santa Maria Public, Meadows Field.

Currently, you can fly between Knoxville and San Luis Obispo with United Airlines, Alaska Airlines.

If you don’t have specific dates for your trip between Knoxville and San Luis Obispo, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Knoxville and San Luis Obispo, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Knoxville. The main one is McGhee Tyson and other nearby airports include Nashville International, McGhee Tyson, Greenville–Spartanburg International, Asheville Regional, Blue Grass, Chattanooga Metropolitan, Tri-Cities Regional

There are a number of airports in and around San Luis Obispo. The main one is San Luis Obispo County Regional and other nearby airports include Fresno Yosemite International, Hollywood Burbank, Monterey Regional, Santa Barbara Municipal, San Luis Obispo County Regional, Santa Maria Public, Meadows Field.