Cheap flights from Des Moines to Charleston from $442

Travelers frequently search for route combinations, such as Des Moines and Phoenix, Fort Lauderdale, Orlando, New York, Salt Lake City, Miami, Mexico City, Los Angeles, Las Vegas, San Francisco, Milan, Santa Ana, Washington, D.C., San Diego, Boston, Punta Gorda, London, León, Toronto, Paris.

Travelers frequently search for route combinations, such as Charleston and Tampa, Orlando, San Diego, Los Angeles, New York, Minneapolis, Seattle, Omaha, Charlotte, Las Vegas, Washington, D.C., Oakland, Denver, Sacramento, Nashville, Honolulu, Cincinnati, New Orleans, Portland, San Antonio.

The main airport in Des Moines is Des Moines International. It is also served by Des Moines International, Eppley Airfield, The Eastern Iowa, Southeast Iowa Regional, Sioux Gateway, Kirksville Regional, Fort Dodge Regional, Mason City Municipal, Waterloo Regional.

The main airport in Charleston is Yeager. It is also served by John Glenn Columbus International, Rickenbacker International, Yeager, Tri-State, Roanoke–Blacksburg Regional, Tri-Cities Regional, North Central West Virginia, Mid-Ohio Valley Regional, Raleigh County Memorial, Greenbrier Valley.

Currently, you can fly between Des Moines and Charleston with United Airlines.

If you don’t have specific dates for your trip between Des Moines and Charleston, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Des Moines and Charleston, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Des Moines. The main one is Des Moines International and other nearby airports include Des Moines International, Eppley Airfield, The Eastern Iowa, Southeast Iowa Regional, Sioux Gateway, Kirksville Regional, Fort Dodge Regional, Mason City Municipal, Waterloo Regional

There are a number of airports in and around Charleston. The main one is Yeager and other nearby airports include John Glenn Columbus International, Rickenbacker International, Yeager, Tri-State, Roanoke–Blacksburg Regional, Tri-Cities Regional, North Central West Virginia, Mid-Ohio Valley Regional, Raleigh County Memorial, Greenbrier Valley.