Cheap flights from Des Moines to Key West from $359

Travelers frequently search for route combinations, such as Des Moines and Phoenix, Fort Lauderdale, Orlando, New York, Salt Lake City, Miami, Mexico City, Los Angeles, Las Vegas, San Francisco, Milan, Santa Ana, Washington, D.C., San Diego, Boston, Punta Gorda, London, León, Toronto, Paris.

Travelers frequently search for route combinations, such as Key West and Orlando, Tampa, Minneapolis, Fort Lauderdale, Detroit, Philadelphia, Washington, D.C., Nashville, Indianapolis, Cincinnati, Atlanta, Portland, Providence, Fort Myers, New York, Plattsburgh, Charlotte, Asheville, Norfolk, Atlantic City.

The main airport in Des Moines is Des Moines International. It is also served by Eppley Airfield, Des Moines International, The Eastern Iowa, Southeast Iowa Regional, Kirksville Regional, Waterloo Regional, Fort Dodge Regional, Mason City Municipal, Sioux Gateway.

The main airport in Key West is Key West International. It is also served by Miami International, Key West International.

Currently, you can fly between Des Moines and Key West with United Airlines.

If you don’t have specific dates for your trip between Des Moines and Key West, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Des Moines and Key West, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Des Moines. The main one is Des Moines International and other nearby airports include Eppley Airfield, Des Moines International, The Eastern Iowa, Southeast Iowa Regional, Kirksville Regional, Waterloo Regional, Fort Dodge Regional, Mason City Municipal, Sioux Gateway

There are a number of airports in and around Key West. The main one is Key West International and other nearby airports include Miami International, Key West International.