Cheap flights from Des Moines, IA to La Serena, Chile

Travelers frequently search for route combinations, such as Des Moines and Los Angeles, Phoenix, Las Vegas, Orlando, Denver, San Francisco, San Diego, Nashville, Salt Lake City, Sacramento, Sarasota, Seattle, Oakland, Washington, D.C., Dallas, Portland, Tampa, Houston, New Orleans, Philadelphia.

Travelers frequently search for route combinations, such as La Serena and Santiago de Chile, Lima, Antofagasta, Iquique, Cusco, Calama, Concepción, Fort Lauderdale, Los Angeles, Tijuana, Punta Arenas, Mendoza, Arica, San José, Buenos Aires, Geneva, Puerto Montt, Richmond, Tallinn, Minneapolis.

The main airport in Des Moines is Des Moines International. It is also served by Des Moines International, Eppley Airfield, The Eastern Iowa, Southeast Iowa Regional, Kirksville Regional, Mason City Municipal, Fort Dodge Regional, Waterloo Regional, Sioux Gateway.

The main airport in La Serena is La Florida. It is also served by La Florida.

Yes, it's possible to combine different modes of transport between Des Moines and La Serena thanks to our Virtual Interlining technology. Making use of not only flights but also trains and buses between Des Moines and La Serena can give rise to new adventures. Read more about how Virtual Interlining works on Kiwi.com Stories.

Virtual Interlining provides a revolutionary way of traveling. You can combine different modes of transport like flights, trains, and buses into one itinerary. And this often saves money. Thanks to the world's largest carrier database, the Kiwi.com search function enables anyone to mix and match different modes of transport easily.

Currently, you can fly between Des Moines and La Serena with Allegiant Air, LATAM Airlines, Spirit Airlines, Sky Airline, JetSMART.

If you don’t have specific dates for your trip between Des Moines and La Serena, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Des Moines and La Serena, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What's more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.