Cheap flights from Houston to Santa Cruz de la Sierra from $318

Travelers frequently search for route combinations, such as Houston and Mexico City, Calgary, Guadalajara, New York, Los Angeles, Toronto, Chicago, Orlando, Las Vegas, Denver, Atlanta, Bogotá, Medellín, Vancouver, Miami, Tokyo, Dallas, Panama, Washington, D.C., Lima.

Travelers frequently search for route combinations, such as Santa Cruz de la Sierra and Washington, D.C., New York, Atlanta, Austin, Chicago, Tampa, Los Angeles, Denver, Minneapolis, Anchorage, Miami, Boston, La Paz, Sucre, Madrid, Cochabamba, Rio de Janeiro, São Paulo, Lima, Asunción.

Houston is mainly served by George Bush Intercontinental. But there are other airports nearby, including William P. Hobby, Ellington, David Wayne Hooks Memorial Airport.

The main airport in Houston is George Bush Intercontinental. It is also served by Austin–Bergstrom International, Jack Brooks Regional, Easterwood, Victoria Regional, Lake Charles Regional.

Currently, you can fly between Houston and Santa Cruz de la Sierra with Frontier Airlines, Boliviana de Aviación, Copa Airlines, LATAM Airlines, Avianca.

If you don’t have specific dates for your trip between Houston and Santa Cruz de la Sierra, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Houston and Santa Cruz de la Sierra, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Houston. The main one is George Bush Intercontinental and other nearby airports include Austin–Bergstrom International, Jack Brooks Regional, Easterwood, Victoria Regional, Lake Charles Regional

This depends on the airline’s flight schedule. You can easily select your preferred departure time when you search on our website or mobile app. Choose the time of day you wish to depart from Houston, such as morning, afternoon, evening, or night, or select the exact hours for departure.