Cheap flights from Des Moines to Palermo from £312

Travelers frequently search for route combinations, such as Des Moines and London, Phoenix, New York, Fort Lauderdale, Orlando, Las Vegas, Washington, D.C., Salt Lake City, San Diego, Miami, Boston, San Francisco, Nashville, Los Angeles, Milan, Tampa, Mexico City, Sarasota, Denver, San Juan.

Travelers frequently search for route combinations, such as Palermo and London, Manchester, Bristol, New York, Edinburgh, Rome, Birmingham, Naples, Prague, Amsterdam, Nice, Barcelona, Copenhagen, Belgrade, Tunis, Paris, Athens, Lisbon, Milan, Belfast.

The main airport in Des Moines is Des Moines International. It is also served by Eppley Airfield, Des Moines International, The Eastern Iowa, Southeast Iowa Regional, Kirksville Regional, Waterloo Regional, Fort Dodge Regional, Mason City Municipal, Sioux Gateway.

The main airport in Palermo is Falcone–Borsellino. It is also served by Catania–Fontanarossa, Falcone–Borsellino, Vincenzo Florio Airport Trapani–Birgi, Pantelleria, Comiso.

Currently, you can fly between Des Moines and Palermo with Allegiant Air, Ryanair, ITA Airways, easyJet, Air France.

If you don’t have specific dates for your trip between Des Moines and Palermo, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Des Moines and Palermo, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Des Moines. The main one is Des Moines International and other nearby airports include Eppley Airfield, Des Moines International, The Eastern Iowa, Southeast Iowa Regional, Kirksville Regional, Waterloo Regional, Fort Dodge Regional, Mason City Municipal, Sioux Gateway

There are a number of airports in and around Palermo. The main one is Falcone–Borsellino and other nearby airports include Catania–Fontanarossa, Falcone–Borsellino, Vincenzo Florio Airport Trapani–Birgi, Pantelleria, Comiso.