Cheap flights from Des Moines, IA to San Francisco, CA

Travelers frequently search for route combinations, such as Des Moines and London, Phoenix, Charlotte, San Antonio, Hurghada, Philadelphia, San Pedro Sula, New York, Salt Lake City, Miami, Denver, Austin, Los Angeles, Cartagena, Amsterdam, Hagerstown, Atlanta, Las Vegas, San Diego, Santa Ana.

Travelers frequently search for route combinations, such as San Francisco and London, Dublin, Manchester, Manila, Athens, Tallinn, New Delhi, Las Vegas, Edinburgh, Denpasar, Bengaluru, Riga, Chennai, Atlanta, Bangkok, Washington, D.C., Hyderabad, Los Angeles, New York, Detroit.

The main airport in Des Moines is Des Moines International. It is also served by Eppley Airfield, Des Moines International, The Eastern Iowa, Southeast Iowa Regional, Kirksville Regional, Sioux Gateway, Fort Dodge Regional, Mason City Municipal, Waterloo Regional.

The main airport in San Francisco is San Francisco International. It is also served by San Francisco International, Sacramento International, Oakland International, San Jose International, Charles M. Schulz–Sonoma County, Stockton Metropolitan, Monterey Regional, Merced Regional, Buchanan Field.

Yes, it's possible to combine different modes of transport between Des Moines and San Francisco thanks to our Virtual Interlining technology. Making use of not only flights but also trains and buses between Des Moines and San Francisco can give rise to new adventures. Read more about how Virtual Interlining works on Kiwi.com Stories.

Virtual Interlining provides a revolutionary way of traveling. You can combine different modes of transport like flights, trains, and buses into one itinerary. And this often saves money. Thanks to the world's largest carrier database, the Kiwi.com search function enables anyone to mix and match different modes of transport easily.

Currently, you can fly between Des Moines and San Francisco with Frontier Airlines, Allegiant Air, United Airlines, Alaska Airlines, Spirit Airlines.

If you don’t have specific dates for your trip between Des Moines and San Francisco, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Des Moines and San Francisco, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What's more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.