Cheap flights from Des Moines, IA to San Antonio, TX

Travelers frequently search for route combinations, such as Des Moines and London, Phoenix, Charlotte, San Pedro Sula, Hurghada, San Diego, Salt Lake City, Los Angeles, New York, Miami, Denver, Austin, Philadelphia, Cartagena, Amsterdam, Hagerstown, Atlanta, Las Vegas, San Francisco, Santa Ana.

Travelers frequently search for route combinations, such as San Antonio and London, Reykjavik, Manila, Manchester, Las Vegas, Taipei, Frankfurt, Phuket City, Toronto, Aguadilla, Dublin, Atlanta, New Orleans, San Juan, Paris, San Diego, Orlando, Salt Lake City, Phoenix, Tapachula.

The main airport in Des Moines is Des Moines International. It is also served by Eppley Airfield, Des Moines International, The Eastern Iowa, Southeast Iowa Regional, Kirksville Regional, Mason City Municipal, Sioux Gateway, Fort Dodge Regional, Waterloo Regional.

The main airport in San Antonio is San Antonio International. It is also served by Austin–Bergstrom International, San Antonio International, Piedras Negras International, Nuevo Laredo International, Laredo International, Corpus Christi International, Killeen–Fort Hood Regional, Victoria Regional, Easterwood.

Yes, it's possible to combine different modes of transport between Des Moines and San Antonio thanks to our Virtual Interlining technology. Making use of not only flights but also trains and buses between Des Moines and San Antonio can give rise to new adventures. Read more about how Virtual Interlining works on Kiwi.com Stories.

Virtual Interlining provides a revolutionary way of traveling. You can combine different modes of transport like flights, trains, and buses into one itinerary. And this often saves money. Thanks to the world's largest carrier database, the Kiwi.com search function enables anyone to mix and match different modes of transport easily.

Currently, you can fly between Des Moines and San Antonio with United Airlines.

If you don’t have specific dates for your trip between Des Moines and San Antonio, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Des Moines and San Antonio, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What's more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.