Cheap flights from Knoxville to Santa Ana from £115

Travelers frequently search for route combinations, such as Knoxville and London, Edinburgh, Fort Lauderdale, Orlando, Houston, Phoenix, Berlin, Destin, Mexico City, Belleville, Reykjavik, Denver, Boston, Ottawa, Ho Chi Minh City, Toronto, St. Louis, Seoul, Chicago, Bucharest.

Travelers frequently search for route combinations, such as Santa Ana and Provo, Calgary, Las Vegas, San Francisco, Vancouver, London, Seattle, Phoenix, Oakland, Denver, Edmonton, Eugene, Boise, Colorado Springs, Hong Kong, Des Moines, Medford, Kelowna, Idaho Falls, Dallas.

The main airport in Knoxville is McGhee Tyson. It is also served by Nashville International, Greenville–Spartanburg International, Asheville Regional, McGhee Tyson, Chattanooga Metropolitan, Blue Grass, Tri-Cities Regional.

The main airport in Santa Ana is John Wayne. It is also served by Tijuana International, San Diego International, John Wayne, Ontario International, Hollywood Burbank, Palm Springs International, Santa Barbara Municipal, Long Beach, Meadows Field, McClellan–Palomar.

Currently, you can fly between Knoxville and Santa Ana with Allegiant Air, United Airlines, Frontier Airlines, BREEZE, JetBlue Airways.

If you don’t have specific dates for your trip between Knoxville and Santa Ana, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Knoxville and Santa Ana, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Knoxville. The main one is McGhee Tyson and other nearby airports include Nashville International, Greenville–Spartanburg International, Asheville Regional, McGhee Tyson, Chattanooga Metropolitan, Blue Grass, Tri-Cities Regional

There are a number of airports in and around Santa Ana. The main one is John Wayne and other nearby airports include Tijuana International, San Diego International, John Wayne, Ontario International, Hollywood Burbank, Palm Springs International, Santa Barbara Municipal, Long Beach, Meadows Field, McClellan–Palomar.