Cheap flights from Knoxville to St. Louis from £126

Travelers frequently search for route combinations, such as Knoxville and London, Edinburgh, Fort Lauderdale, Orlando, Houston, Phoenix, Berlin, Destin, Mexico City, Belleville, Reykjavik, Denver, Boston, Ottawa, Ho Chi Minh City, Toronto, Seoul, Chicago, Bucharest, Ahmedabad.

Travelers frequently search for route combinations, such as St. Louis and London, Denver, Orlando, Las Vegas, Toronto, Fort Lauderdale, Dallas, Los Angeles, Bogotá, Mexico City, Edmonton, Guadalajara, Tokyo, Reykjavik, Buenos Aires, Minneapolis, Frankfurt, Winnipeg, Yerevan, Accra.

The main airport in Knoxville is McGhee Tyson. It is also served by Nashville International, McGhee Tyson, Asheville Regional, Greenville–Spartanburg International, Chattanooga Metropolitan, Blue Grass, Tri-Cities Regional.

The main airport in St. Louis is St. Louis Lambert International. It is also served by St. Louis Lambert International, MidAmerica St. Louis, Evansville Regional, Abraham Lincoln Capital, General Wayne A. Downing Peoria International, Central Illinois Regional, Waynesville-St. Robert Regional, Columbia Regional, Cape Girardeau Regional, Williamson County Regional.

Currently, you can fly between Knoxville and St. Louis with Frontier Airlines, Allegiant Air, United Airlines, Spirit Airlines, WestJet.

If you don’t have specific dates for your trip between Knoxville and St. Louis, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Knoxville and St. Louis, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Knoxville. The main one is McGhee Tyson and other nearby airports include Nashville International, McGhee Tyson, Asheville Regional, Greenville–Spartanburg International, Chattanooga Metropolitan, Blue Grass, Tri-Cities Regional

There are a number of airports in and around St. Louis. The main one is St. Louis Lambert International and other nearby airports include St. Louis Lambert International, MidAmerica St. Louis, Evansville Regional, Abraham Lincoln Capital, General Wayne A. Downing Peoria International, Central Illinois Regional, Waynesville-St. Robert Regional, Columbia Regional, Cape Girardeau Regional, Williamson County Regional.