Cheap flights from Madrid to Panama City from £564

Travelers frequently search for route combinations, such as Madrid and London, Manchester, Edinburgh, Lisbon, Paris, Amsterdam, Barcelona, Rome, Glasgow, Bristol, Tenerife, Belfast, Birmingham, Mexico City, Tel Aviv, Milan, Newcastle upon Tyne, Warsaw, Budapest, Berlin.

Travelers frequently search for route combinations, such as Panama City and Cartagena, Panama, Key West, Algiers, Houston, Muscat, Destin, Ho Chi Minh City, Lisbon, Cali, Tenerife, Abuja, Santorini, Accra, Sofia, Tirana, Barcelona, Chișinău, Knoxville, Santa Marta.

The main airport in Madrid is Adolfo Suárez Madrid–Barajas. It is also served by Salamanca, Valladolid.

The main airport in Panama City is Northwest Florida Beaches International. It is also served by Pensacola International, Destin–Fort Walton Beach, Tallahassee International, Montgomery Regional, Dothan Regional, Southwest Georgia Regional, Valdosta Regional.

Currently, you can fly between Madrid and Panama City with WestJet, Air Canada, Iberia Airlines, KLM Royal Dutch Airlines, Air Transat.

If you don’t have specific dates for your trip between Madrid and Panama City, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Madrid and Panama City, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Madrid. The main one is Adolfo Suárez Madrid–Barajas and other nearby airports include Salamanca, Valladolid

There are a number of airports in and around Panama City. The main one is Northwest Florida Beaches International and other nearby airports include Pensacola International, Destin–Fort Walton Beach, Tallahassee International, Montgomery Regional, Dothan Regional, Southwest Georgia Regional, Valdosta Regional.