Cheap flights from Santo Domingo, Dominican Republic to Mayagüez, United States

Travelers frequently search for route combinations, such as Santo Domingo and London, New York, Bogotá, San Juan, Manchester, Toronto, Montreal, Houston, Edmonton, Mexico City, Port-au-Prince, Cartagena, Tampa, Istanbul, Charlotte, Guadalajara, Dallas, Boston, Barcelona, Madrid.

Travelers frequently search for route combinations, such as Mayagüez and Los Angeles, Denver, New York, Orlando, Las Vegas, Chicago, Miami, Atlanta, Mexico City, Bogotá, Dallas, Phoenix, Philadelphia, San Francisco, Cancún, Houston, San Juan, Washington, D.C., Dhaka, Fort Lauderdale.

Santo Domingo is mainly served by Las Américas International. But there are other airports nearby, including La Isabela International.

The main airport in Santo Domingo is Las Américas International. It is also served by Punta Cana International, Cibao International, Gregorio Luperón International, La Romana International, Samaná El Catey International.

The main airport in Mayagüez is Eugenio María de Hostos. It is also served by Luis Muñoz Marín International, Aguadilla Rafael Hernandez, Fernando Luis Ribas Dominicci, José Aponte de la Torre, Eugenio María de Hostos, Mercedita.

Yes, it's possible to combine different modes of transport between Santo Domingo and Mayagüez thanks to our Virtual Interlining technology. Making use of not only flights but also trains and buses between Santo Domingo and Mayagüez can give rise to new adventures. Read more about how Virtual Interlining works on Kiwi.com Stories.

Virtual Interlining provides a revolutionary way of traveling. You can combine different modes of transport like flights, trains, and buses into one itinerary. And this often saves money. Thanks to the world's largest carrier database, the Kiwi.com search function enables anyone to mix and match different modes of transport easily.

Currently, you can fly between Santo Domingo and Mayagüez with Cape Air, JetBlue Airways, Frontier Airlines, Spirit Airlines, Copa Airlines.

If you don’t have specific dates for your trip between Santo Domingo and Mayagüez, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.