Cheap flights from Madrid to Santa Ana from $618

Travelers frequently search for route combinations, such as Madrid and New York, Miami, Los Angeles, Houston, Orlando, Dallas, Boston, Washington, D.C., Chicago, San Diego, Atlanta, Lisbon, Warsaw, Raleigh, Las Vegas, San Francisco, Barcelona, San Juan, Seattle, Rome.

Travelers frequently search for route combinations, such as Santa Ana and Provo, San Francisco, Las Vegas, Seattle, Phoenix, Oakland, Vancouver, Denver, Eugene, Boise, New York, Idaho Falls, Medford, Des Moines, Dallas, Colorado Springs, Washington, D.C., Portland, London, New Orleans.

The main airport in Madrid is Adolfo Suárez Madrid–Barajas. It is also served by Valladolid, Salamanca.

The main airport in Santa Ana is John Wayne. It is also served by Tijuana International, San Diego International, Ontario International, John Wayne, Palm Springs International, Hollywood Burbank, Santa Barbara Municipal, Long Beach, Meadows Field, McClellan–Palomar.

Currently, you can fly between Madrid and Santa Ana with Alaska Airlines, Frontier Airlines, Iberia Airlines, TAP Portugal, Air Europa.

If you don’t have specific dates for your trip between Madrid and Santa Ana, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Madrid and Santa Ana, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Madrid. The main one is Adolfo Suárez Madrid–Barajas and other nearby airports include Valladolid, Salamanca

There are a number of airports in and around Santa Ana. The main one is John Wayne and other nearby airports include Tijuana International, San Diego International, Ontario International, John Wayne, Palm Springs International, Hollywood Burbank, Santa Barbara Municipal, Long Beach, Meadows Field, McClellan–Palomar.