Cheap flights from Prague to Chicago

Travelers frequently search for route combinations, such as Prague and London, Manchester, Dublin, Edinburgh, Athens, Reykjavik, Toronto, Sofia, Birmingham, Thessaloniki, Liverpool, Vancouver, Tallinn, Glasgow, Montreal, Bristol, New York, Kutaisi, Malta, Barcelona.

Travelers frequently search for route combinations, such as Chicago and London, Dublin, Manchester, Toronto, Athens, Orlando, San Francisco, Hyderabad, Vilnius, New York, Las Vegas, Edinburgh, Denver, Bangkok, Minneapolis, Riga, Glasgow, Austin, San Juan, Edmonton.

The main airport in Prague is Václav Havel Airport Prague. It is also served by Václav Havel Airport Prague, Copernicus Airport Wrocław, Brno–Tuřany, Dresden, Leipzig/Halle Airport, Pardubice Airport, Linz, Karlovy Vary.

The main airport in Chicago is O Hare International. It is also served by General Mitchell International, Gerald R. Ford International, Dane County Regional, Fort Wayne International, General Wayne A. Downing Peoria International, South Bend International, Central Illinois Regional, Quad City International, Kalamazoo/Battle Creek International, Decatur.

A number of bus and train companies depart from Prague, including Czech Rail train.

Yes, it's possible to combine different modes of transport between Prague and Chicago thanks to our Virtual Interlining technology. Making use of not only flights but also trains and buses between Prague and Chicago can give rise to new adventures. Read more about how Virtual Interlining works on Kiwi.com Stories.

Virtual Interlining provides a revolutionary way of traveling. You can combine different modes of transport like flights, trains, and buses into one itinerary. And this often saves money. Thanks to the world's largest carrier database, the Kiwi.com search function enables anyone to mix and match different modes of transport easily.

Currently, you can fly between Prague and Chicago with Delta Air Lines, United Airlines, Lufthansa, Ryanair.

If you don’t have specific dates for your trip between Prague and Chicago, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.